Publications

The Hjelt Foudation grant holders names are indicated in bold.
This pdf file (August 2018) follows our grant holders Acknowledged in Articles since 2009.

2018

Cai M. et al. Role of osteopontin and its regulation in pancreatic islet. BBRC 495:1426-1431, 2018.

Rutti S., Dusaulcy R., Hansen JS, Howald C, Dermitzakis E.T., Pedersen B.K., Pinget M., Plomgaard P. & Bouzakri K. Angiogenin and Osteoprotegerin are type II muscle specific myokines protecting pancreatic beta-cells against proinflammatory cytokines. Sci Rep. 8: 10072, 2018.

Andersson L., Shcherbina L., Al-Majdoub M., Vishnu N., Arroyo CB, Carrara JA, Wollheim CB, Fex M., Mulder H., Wierup N. & Spégel P. Glutamine-elicited secretion of glucagon-like peptide 1 is governed by an activated glutamate dehydrogenase. Diabetes 67(3):372-384, 2018.

Amisten S., Duner P., Asplund O., Mohammed Al-Amily I., Groop L. & Salehi A. J.: Activation of imidazoline receptor I2, and improved pancreatic β-cell function in human islets. Diabetes Complic. 32(9):813-818, 2018.

2017

Axelsson AS et al. (Rosengren A) Sox 5 regulates beta-cell phenotype and is reduced in type 2 diabetes. Nat. Communic. 8:15652, 2017.

Axelsson AS et al. (Rosengren A), Sulforaphane reduces hepatic glucose production and improves glucose control in patients with type 2 diabetes.  Sci. Translat. Med. 9(394), 2017.

Ofori JK, Salunkhe VA, Bagge A,Vishnu N, Nagao M, Mulder H, Wollheim CB, Eliasson L & Esguerra JL. Elevated miR-130a/miR130b/miR-152 expression reduces intracellular ATP levels in the pancreatic beta cell. Sci. Rep. 7:44986, 2017.

Portius D., Sobolewski C. & Foti M. MicroRNAs-Dependent regulation of PPARs in metabolic diseases and cancers. PPAR Res. 7058424, 2017.

Säll J., Pettersson A.M. L., Björk C., Henriksson E., Wasserstrom S., Linder W., Zhou Y., Hansson O.,  Andersson  D.P., Ekelund M., Degerman E., Stenkula K.G., Laurencikiene J. & Göransson O: Salt-inducible kinase 2 and -3 are downregulated in adipose tissue from obese or insulin-resistant individuals: implications for insulin signalling and glucose uptake in human adipocytes. Diabetologia (60)2:314-323, 2017.

Petrenko V., Gosmain Y. & Dibner C. High-Resolution Recording of the Circadian Oscillator in Primary Mouse α- and β-Cell Culture. Front Endocrinol. (Lausanne) 8:68, 2017.

Gachon F., Loizides-Mangold U., Petrenko V. & Dibner C. Glucose Homeostasis: Regulation by Peripheral Circadian Clocks in Rodents and Humans. Endocrinology (5):1074-1084, 2017.

Petrenko V., et al. (Dibner C) Pancreatic α- and β-cellular clocks have distinct molecular properties and impact on islet hormone secretion and gene expression. Genes Dev. 31(4):383-398, 2017.

Petrenko V. & Dibner C. Cell-specific resetting of mouse islet cellular clocks by glucagon, glucagon-like peptide 1 and somatostatin. Acta Physiol. 222(4):e13021, 2017.

Al-Majdoub M., Geidenstam N., Ali A., Ridderstråle M., Storm P., Groop L., Bennet L., Spégel P. Branched-chain amino acids are associated with odd-chain fatty acids in normoglycaemic individuals. DiabetesMetab. S1262-3636(16)30576-6, 2017.

Brun J., Berthou F., Trajkovski M., Maechler P., Foti M. & Bonnet N: Bone regulates browning and energy metabolism through mature osteoblast/osteocyte PPARγ expression. Diabetes (10): 2541-2554, 2017.

Arous C. & Wehrle-Haller B.: Role and impact of the extracellular matrix on integrin-mediated pancreatic β-cell functions. Biol. Cell. 109(6):223-237, 2017.

Brenachot X., Ramadori G., Ioris RM, Veyrat-Durebex C., Altirriba J., Aras E., Ljubicic S., Kohno D., Fabbiano S., Clement S., Goossens N., Trajkovski M., Harroch S., Negro F. & Coppari R. Hepatic protein tyrosine phosphatase receptor gamma links obesity-induced inflammation to insulin resistance. Nature Commun. 8(1):1820, 2017

2016

De Marinis Y., Cai M., Bompada P., Atac D., Kotova O., Johansson ME, Garcia-Vaz E., Gomez MF., Laakso M. & Groop L. Kidney Int. 89(2):342-53, Epigenetic regulation of the thioredoxin-interacting protein (TXNIP) gene by hyperglycemia in kidney. 2016

Saini C, Petrenko V, Pulimeno P, Giovannoni L, Berney T, Hebrok M, Howald C, Dermitzakis ET, Dibner C. Diabetes Obes Metab. 2016 Apr;18(4):355-65. doi: 10.1111/dom.12616. Epub 2016 Jan 22. A functional circadian clock is required for proper insulin secretion by human pancreatic islet cells.

Cai M., Bompada P., Atac D., Laakso M., Groop L. &De Marinis Y. BBRC 469: 109-13: Epigenetic regulation of glucose-stimulated osteopontin expression in diabetic kidney. 2016

Calo N., Ramadori P., Sobolewski  C., Romero Y., Maeder C., Fournier M.  Rantakari P., Zhang F.P., Poutanen M., Dufour J.F., Humar B., Nef S. & Foti M. Stress-activated miR-21/miR-21* in hepatocytes promotes lipid and glucose metabolic disorders associated with high-fat diet consumption. Gut 65(11):1871-1881, 2016.

Heni M., Kullmann S., Ahlqvist E., Wagner R., Machicao F., Staiger H., Häring H., Almgren P., Groop L.C., Small D.M., Fritsche A. & Preissl H: Interaction between the obesity-risk gene FTO and the dopamine D2 receptor gene ANKK1/TaqIA on insulin sensitivity. Diabetologia 59(12):2622-2631, 2016.

2015

Asrish M., Montessuit C., Philippe J. & Jornayvaz FR. Cell Physiol. Biochem. 37:1767-1778 Free fatty acids impair FGF21 action in HepG2 cells. 2015

Asrih M., Altirriba J., Rohner-Jeanrenaud F. & Jornayvaz FR. PLoS One 10(5):e0126364, Ketogenic diet impairs FGF signalling and promotes differential inflammatory responses in the liver and white adipose tissue. 2015

Hänzelmann S. et al. (Rosengren A) Thrombin stimulates insulin secretion via protease-activated receptor-3. Islets 7(4):e1118195, 2015.

2014

Zhou Y. et al. Hansson O, Human Mol. Gen. 23, (24): 6419-31: TCF7L2 is a master regulator of insulin production and processing. 2014

Tang Y., Axelsson AS, Spégel P., Andersson LE, Mulder H., Groop LC, Renström E. & Rosengren AH. Science Translat. Med. 6 (257):257ra139 Genotype-based treatment of type 2 diabetes with an α2A-adrenergic receptor antagonist. 2014

Esguerra J.L. S., Mollet I.G. , Salunkhe V.A. , Wendt A. & Eliasson L. Genes 5, 1018-1031, Regulation of Pancreatic Beta Cell Stimulus-Secretion Coupling by microRNAs. 2014

2013

Asrih, M. and Jornayvaz, F: Inflammation as a link between nonalcoholic fatty liver disease and insulin resistance. Review J. of Endocrinol. in Press.

Jonsson A, Ladenvall C, Ahluwalia TS, Kravic J, Krus U, et al. (2013) Effects of common genetic variants associated with type 2 diabetes and glycemic traits on alpha- and beta-cell function and insulin action in humans. Diabetes 62: 2978-2983.

2012

Vetterli, L., Carobbio, S., Pournourmohammadi, S., Martin-Del-Rio, R., Skytt, D.M., Waagepetersen, H.S., Tamarit-Rodriguez, J. and Maechler, P.: Delineation of glutamate pathways and secretory responses in pancreatic islets with beta-cell-specific abrogation of the glutamate dehydrogenase. Mol. Biol. Cell. 19:3851-62, 2012.

2011

Feldmann, N., del Rio, R.M., Gjinovci, A., Tamarit-Rodriguez, J., Wollheim, C.B. and Wiederkehr, A.: Reduction of plasma membrane glutamate transport potentiates insulin but not glucagon secretion in pancreatic islet cells. Mol. Cell Endocrinol. 338(1-2):46-57, 2011.

Ahluwalia TS, Lindholm E, Groop LC (2011) Common variants in CNDP1 and CNDP2, and risk of nephropathy in type 2 diabetes. Diabetologia 54: 2295-2302.

Ahluwalia TS, Lindholm E, Groop L, Melander O (2011) Uromodulin gene variant is associated with type 2 diabetic nephropathy. J Hypertens 29: 1731-1734.

Ahlqvist E, Ahluwalia TS, Groop L (2011) Genetics of type 2 diabetes. Clin Chem 57: 241-254.

Cai M, de Marinis Y, Acosta J, Kotova O, Gomez M, Laakso M and Groop L. Hyperglycemia-induced histone modifications and expression of proinflammatory genes in kidney.