Yang De Marinis

Yang De Marinis

Hjelt grant holder 2017, Lund university

New Epigenetic Targets for Diabetic Kidney Disease Prediction

Diabetic kidney disease affects almost 30 percent of diabetic patients and is a prime reason for kidney function loss. High blood glucose may contribute to diabetic kidney disease progression, and several studies including my previous publications have shown that diabetic kidney disease development may involve glucose-triggered epigenetic changes, which will be the focus of this project.

Epigenetic changes may occur via modifications on the histone proteins, around which the DNA strand winds and packs into chromosome structure. Based on our previous research, we suggest that glucose may modify histones on various locations, leading to changes in DNA packaging structure, and consequently affects gene activity that contributes to diabetic kidney disease development. Here we will make detailed analysis on histone modifications in blood from diabetic patients with Diabetic kidney disease, and associate these changes to diabetic kidney disease risk.

This study will hopefully contribute to better understanding of diabetic kidney disease pathogenesis. The epigenetic markers in blood identified in this project may be used as predictive biomarkers for diabetic kidney disease. Once validated, patients can be screened by simple blood tests for presence of these markers without invasive biopsy procedures. Patients at high diabetic kidney disease risk can be thereby identified to allow intensified therapy to prevent diabetic kidney disease. 

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